Senior Scientist Ii, Abbvie Biotherapeutics

Job Description
Key Responsibilities
Conceive &
execute novel scientific research or development that achieves projects &
area goals.
Generate new scientific proposals &
lead those efforts.
Investigate, identify, develop, &
optimize new methods &
techniques.
Act as a lead in area of expertise &
critically evaluate relevant scientific &
regulatory advances &
integrate this knowledge into research or development programs.
Conceive &
implement novel experimental approaches to answer scientific questions &
enable the development of antibody drug conjugates (ADCs) for the treatment of cancer.
Responsible for conceiving &
performing studies, as well as analyzing &
interpreting results &
effectively communicatefindings in a group setting.
Maintain solid understanding &
hands-on-experience assessing key cancer cell signaling pathways such as investigating, identifying, developing, &
optimizing new methods &
techniques that inform on pathway/drug mechanisms of action such as flow cytometry, biochemical assays, reporter assays, or gene over-expression/knockdown.
Identify, develop, &
optimize new methods &
techniques that inform on ADC/payload mechanism of actions using flow cytometry, biochemical assays, reporter assays or gene overexpression/knockdown.
Perform flow cytometry studies to interrogate antibody binding to cells of interest and analysis using FlowJo.
Generate &
analyze omic datasets such as scRNAseq, RNA-seq or phospho-proteomic datasets to identify pharmacodynamic (PD) or resistance biomarkers.
Responsible for validating PD &
resistance biomarker utilizing immunoblot, qRT-PCR or flow cytometry.
Understand &
adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug &
radioactive compounds, GxP compliance, &
animal care where applicable.
Responsible for leading presentations at International Scientific meetings.
Manage &
oversee lower-level scientists within division.
Conduct medium- or high- throughput compound screening to identify combination partners that are clinically actionable &
demonstrate the strength of their interaction utilizing synergy calculating software