Senior Scientist I

Job Description
Key Responsibilities
Responsible for developing, optimizing &
executing new analytical methods &
techniques to characterize complex proteins/glycoproteins, antigens &
novel protein-based therapeutics.
Work within multi-disciplinary project teams &
act as a lead analytical &
biophysical resource toguide development &
advance pipeline.
Resolve key project challenges by effectively utilizing available analytical tools, information &
technical expertise.
Develop, optimize &
execute new analytical methods &
techniques to characterize complex proteins/glycoproteins, antigens &
novel protein-based therapeutics.
Strategically advance scientific expertise within the Analytics group by conceiving &
executing novel scientific research &
development efforts to address project challenges &
provide novel insights.
Demonstrate leadership by advising &
sharing knowledge &
expert opinions with peers &
senior management.
Contribute to research that leads to peer-reviewed publications, reports &
external presentations.
Employ experience in protein analytical &
biophysical characterization to discern protein critical quality attributes (physiochemical properties, post-translational modifications) &
better understand protein structure-function relationships.
Work in cross-functional teams with scientists across functions &
therapeutic areas (Virology, Immunology, Oncology &
Neuroscience) to discover &
develop next generationbiologics through interrogation &
engineering of protein attributes across both targets and therapeutic molecules.
Responsible for utilizing verbal &
written skills &
the ability to clearly present scientific concepts &
results for functional scientific &
non-scientific leaders.
Employ experience with in-depth protein analytical characterization using a variety of techniques such as LC-MS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF.
Employ experience utilizing various software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, &
ImageJ.
Responsible for demonstrating proficiency with various chromatographic techniques, capillary electrophoresis methodologies &
in-depth biophysical characterization.
Responsible for preparation and characterization of disease-relevant proteins in defined morphological states. Employ experience in guiding recombinant protein expression &
purification.
Employ experience with protein labeling &
conjugation, as well asprotein formulation &
remediation. Prepare written documentation, reports &
presentations of work &
strategies.
Work on the selection of targets or variants for therapeutic development &
include the design, engineering &
characterization of resulting therapeutics &
their mechanisms of action.
Employ experience with routine mass spectrometry workflows, including intact &
subunit analysis.
Responsible for project driven initiatives that will require scientific exploration &
experimentation as wellas close collaboration with scientists across the organization.
Responsible for new technology development by expanding analytical expertise &
custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering &
developing novel therapeutics.