Senior Scientist I - Purification Process Development

Job Description
The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bio-specifics, gene therapy, etc. Ideal candidate will conceive and implement novel experimental and/or modeling approaches to answer scientific questions. The mission of this team is to address challenging problems in biologics development areas by working collaboratively and cross-functionally by developing appropriate tools and technologies to enable right at first pass scale-up and technology transfer of various biologics modalities drug substance processes.
Responsibilities:
Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for monoclonal antibodies, bio-specifics and antibody drug conjugates (ADC).
Proactively seek opportunities to come up with innovative solutions to cater challenging business problems through creative solutions.
Design and execute process development and characterization activities, impurity and viral clearance studies.
Provide deeper understanding of process performance using appropriate experimental and modeling tools.
Responsible for technology transfer to pilot lab and cGMP manufacturing facilities, troubleshooting and investigation activities.
Harness power of strong fundamentals to come up with innovative process and/or equipment designs in a strongly collaborative environment.
Build experimentally verified fit for purpose mathematical models for downstream purification processes.
Routinely demonstrate scientific initiative and creativity in research or development activities.
Exhibit a strong motivation to implement and advance various innovative technologies in relevant areas across AbbVie.
Highly independent and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
Formulate conclusions and design follow-on experiments based on multidisciplinary data.
A primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
Maintain a high level of productivity in the lab and/or pilot plant and cGMP manufacturing facilities.
Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.No description available