Senior Director, Dmpk

Job Description
The Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.
Provide DMPK scientific leadership across all stages of the portfolio.
Oversee the quality and performance of all DMPK activities including interactions with external CRO’s and internal project stakeholders.
Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion.
Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
Work closely with discovery team and regulatory team to author and review DMPK related IND documents
Managing DMPK budgets for CRO’s and monitoring CROs to ensure delivery of quality data on time.
Support leadership of the Quantitative Pharmacology group and junior staff development