Principal Research Scientist I, Lipid Nanoparticle Formulation And Drug Delivery

Job Description
The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaborativelyprogress candidates with higher probability of success intodevelopment and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientistswork in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.
Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select formulations with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo delivery challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving.
AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Principal Research Scientist I position. The primary role of this position is to serve as an MPDD project leader on discovery programs, leading CMC development of lipid nanoparticle formulations. This role will also entail contributing towards developing our drug delivery capabilities with a focus on lipid nanoparticle manufacturing, analytical testing, characterization, and development. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of this modality and advance formulations to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, lipid nanoparticle manufacturing and characterization techniques, as well as drug delivery concepts relevant to nanoparticle-based medicines.
Key Competencies
Builds strong relationships with peers and cross-functional partners to enable higher performance.
Learns fast, grasps the "
Essence”, and can changecourse quickly where indicated.
Connects ideas from disparate fields, integrates data and information quickly, and takes risks to achieve the highest performance.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.